Most common fibroosseous lesion encountered in clinical. F ibrous dysplasia fd is the most common benign fibro. Cod denotes an extensive process with multifocal involvement of the jaws by lesional tissue with the same microscopic. Fibroosseous lesions fols are the group of lesions which are recognized to affect the jaws and the craniofacial bones which are known for their confusing area in diagnostic pathology. Fibro osseous lesions comprise a group of disorders characterized histologically by replacement of normal bone by cellular fibrous tissue within which varying amount of predominantly woven bone and acellular islands of mineralized tissue develops. Fibroosseous lesions of the oral and maxillofacial region. This matrix displays varying degrees of mineralization in the form of woven bone or of cementumlike round acellular intensely basophilic structures. They are mostly characterized by the replacement of bone by a benign connective tissue. Benign fibroosseous lesions of the craniofacial skeleton bfol are a variant group of intraosseous disease processes that share similar microscopic features characterized by hypercellular fibroblastic stroma containing various combinations of bone or cementumlike tissue and other calcified structures 16.
Benign fibro osseous lesions is a group of lesions in which normal bone is replaced initially by fibrous connective tissue and over a period of time, the lesion is infiltrated by osteoid and cementoid tissue. Benign fibro osseous condition involving one or more bones of the cranial and extracranial skeleton, consists of nonencapsulated lesions which show replacement of normal bone by cellular fibrous tissues edwards 1984 originally introduced by lichtenstein in 1938 one of the most perplexing diseases of osseous tissues. A clinicopathologic analysis of 207 cases of benign fibro. Among them, fibrous dysplasia has been reported to result from activating mutations of the gnas1 gene encoding the subunit of stimulatory g. Florid cementosseous dysplasia of maxilla and mandible. Fibroosseous lesions of the face and jaws request pdf. Request pdf fibroosseous lesions of the face and jaws maxillofacial fibroosseous lesions fol consists of lesions that differ, with the exception of fibrous dysplasia, to those found in the. Benign fibroosseous lesions of the craniofacial complex. Fibroosseous lesions of the jaws comprise a diverse group of conditions, which are characterized by replacement of normal bone by fibroblasts, collagen fibers, and mineralized tissue. Benign fibroosseous lesions of the jaws pocket dentistry. Pattern of fibroosseous lesions of jaws in port harcourt. Victor boyko presented a case of osteofibroma of the mandible associated with leontiasis ossea of the skull boyko gv.
As a group, they are relatively common in the craniofacial complex, especially the jaws. Benign fibroosseous lesions is a group of lesions in which normal bone is replaced initially by fibrous connective tissue and over a period of time, the lesion is infiltrated by osteoid and cementoid tissue. This entity occurs more commonly in females and has a predilection for african americans. The article pitches a bright on the various classification systems are. Commonly included among the fibroosseous lesions of the jaws are fibrous dysplasia, cemento osseous dysplasia, and ossifying fibroma.
Fibro osseous lesions classifications, pathophysiology and. Whereas some are diagnosable histologically, most require a combined assessment of. Fibroosseous lesions in adults have been well documented in many studies and although they often occur in children and adolescents, relevant reports are rather infrequent. Fibro osseous lesions of the jaws as a generic term used to describe a number of apparently different pathologic entities that commonly affect the maxilla, mandible and other facial bones1. Special emphasis on satb2 expression in osseous lesions of. Fibro osseous lesion fol is a broad term for a diverse group of jaw and craniofacial disorders that are often painless but grow progressively if uncontrolled. Fibro osseous lesions are a diverse group of processes that are characterized by replacement of normal bone by fibrous tissue containing a newly formed mineralized product. Mdm2 and cdk4 immunohistochemistry is a valuable tool in the differential diagnosis of lowgrade osteosarcomas and other primary fibroosseous lesions of the bone. Five osseous lesions of the jaw were evaluated, including 2 oss one arising in fibrous dysplasia, and the other fibroblastic variant, one fibrosarcoma arising in ameloblastoma, and two fibromyxomas of mandible.
Fibroosseous lesions are characterized by the presence of bone marrow that has changed into fibrous tissue and that contains mineralized material of varying appearances. Fibrous dysplasia is a tumor like developmental condition, characterised by proliferation of abnormal cellular fibrous connective tissue with irregular trabe. Fibroosseous lesions of the head and neck diagnostic. Case reports have been published on families presenting. Fibro osseous lesions classifications, pathophysiology. Journa of enta an ra eath 9 s e e pwt scientonlineorg ent oral ealth issn 23 research article scient open access exploring the world of science pattern of fibro osseous lesions of the jaws in kano, northern nigeria sule aa 1, iyogun ca2 and adeyemi te3 1department of pathology, bayero university kano aminu kano teaching hospital, kano. Fibro osseous lesions of jaws dental implant courses by. Fibroosseous lesions of jaw are a diverse group and since it may not be possible to adequately separate them. Focal osseous dysplasia europe pmc article europe pmc. Ppt fibroosseous lesions powerpoint presentation free to. It will become apparent that for this group of conditions, diagnosis. Fibro osseous lesions fol are a poorly defined group of lesions affecting the jaws and craniofacial bones. Nov 20, 2014 benign fibroosseous lesions of the craniofacial skeleton bfol are a variant group of intraosseous disease processes that share similar microscopic features characterized by hypercellular fibroblastic stroma containing various combinations of bone or cementumlike tissue and other calcified structures 16.
View enhanced pdf access article on wiley online library html view download pdf for offline viewing. Benign fibro osseous lesions occur commonly in the jaw. Ossifying fibromas are typically encapsulated, circumscribed, benign neoplasms made up of highly cellular fibrous connective tissue that contains varying amounts of osteoid, bone, cementum. Management and treatment outcomes of maxillofacial fibro. Cementoosseous dysplasia may occur in the toothbearing jaw after dental extraction, and when multiple lesions are present, adjacent periapical lesions may coalesce.
Fibroosseous lesions of jaws were more in females 61. Ossifying fibromas are typically encapsulated, circumscribed, benign neoplasms made up of highly cellular fibrous connective tissue that contains varying. Shiping wang and yifang zhao, benign fibro osseous lesions of the jaws. This chapter demonstrates the variation in the radiological appearances of conditions of fibro. Other cemento osseous dysplasias defined as lesions which share some of the features of periapical cemental dysplasia andor florid cemento osseous dysplasia, but do not have their characteristic clinicopathological patterns of presentation. Fibro osseous lesions 1 fibro osseous lesions dr shabeel pn 2 introduction. Focal osseous dysplasia fod is one of the benign fibroosseous lesions of the jaw bones and the most commonly occuring benign fibroosseous lesion. Fibroosseous lesions the term fibroosseous lesion fol is a generic designation of a group of jaw disorders characterized by the replacement of bone by a benign connective tissue matrix. Despite the histologic ubiquity, their behaviors vary significantly. Fibroosseous lesions, africa, bone dysplasia, fibrous dysplasia, molecular diagnosis, ossifying fibroma. Fibroosseous lesions fol represent a varied group of entities in which the normal bone is replaced by cellular fibrous tissue containing mineralized foci that may vary in amount and appearance. Because of the histologic similarity and the broad range of morbidity among them, it is important to be able to differentiate between them in the. In this study, we examined the epidemiological, clinical, and path. Nov 28, 2005 fibro osseous lesions are a poorly defined group of lesions affecting the jaws and craniofacial bones.
Such lesions are characterized by replacement of normal bone with cellular fibrous tissue and newly formed osseous cemento osseous deposits. Oct 28, 2016 fibro osseous lesions are grouped together because histologically they show similar cellular and mineralization patterns. Fibroosseous lesions are a poorly defined group of lesions affecting the jaws and craniofacial bones. Cementoosseous dysplasia occurs in the tooth bearing areas of the jaws. Benign fibroosseous lesions bfol of the jaw, facial and skull bones are a variant group of intraosseous disease processes that share microscopic features 14. Clinical study of benign and malignant fibrous osseous lesions of the jaws 33 of follow up, 5 of 8 cases survived. Benign fibroosseous lesions of the craniofacial complex a. Mdm2 and cdk4 immunohistochemistry is a valuable tool in the differential diagnosis of lowgrade osteosarcomas and other primary fibro osseous lesions of the bone. Jan 31, 2017 fibrous dysplasia is a tumor like developmental condition, characterised by proliferation of abnormal cellular fibrous connective tissue with irregular trabe. The brown tumor of hyperparathyroidism, a giant cell lesion, may be encountered anywhere in the skeleton in both primary and. Clinical study of benign and malignant fibrousosseous lesions of the jaws 33 of follow up, 5 of 8 cases survived.
Pattern of fibroosseous lesions of jaws in port harcourt in. The diagnostic dilemma faced is that of benign fibroosseous lesions, a partial list of entities encompassed by this term includes fibrous dysplasia, cherubism, ossifying and cementifying fibroma, pagets disease, and cementoosseous dyaplasia. The term fol is a generic designation of a group of bone disorders characterized by the replacement of bone by a benign connective tissue matrix that displays varying degrees of mineralization in the form of woven bone or cementum. Fibroosseous lesions are a group of bone disorders in which the. Fibro osseous lesions fol represent a varied group of entities in which the normal bone is replaced by cellular fibrous tissue containing mineralized foci that may vary in amount and appearance. Ppt fibroosseous lesions powerpoint presentation free. Pattern of fibroosseous lesions of jaws in port harcourt in southsouth nigeria authors. These form a diverse group of conditions with differing aetiologies but similar histological appearances. Fibroosseous lesions of the jaws in ibadan, nigeria. Retrospective survey of the records of all patients with histopathological diagnosis of fibro osseous lesion. Such lesions are characterized by replacement of normal bone with cellular fibrous tissue and newly formed osseous cementoosseous deposits. Benign fibroosseous lesions of the jaws request pdf. Journa of enta an ra eath 9 s e e pwt scientonlineorg ent oral ealth issn 23 research article scient open access exploring the world of science pattern of fibroosseous lesions of the jaws in kano, northern nigeria sule aa 1, iyogun ca2 and adeyemi te3 1department of pathology, bayero university kano aminu kano teaching hospital, kano. Radiographically, fibroosseous lesions vary considerably from a simple radiolucent lesion to mixed radiolucent radiopaque or radiopaque lesion.
They are characterized by the replacement of normal bone by fibrous connective tissue matrix displaying varying degrees of mineralization in the form of woven bone or cementumlike structures. Continuous observations on osteosarcoma and ewings sarcoma are very important and should be checked every two months after surgery. Differential diagnosis of fibrous dysplasia and fibro osseous neoplastic lesions of the jaws and their treatment. The aim of the study was to detect satb2 expression in os and other bony lesions of the jaw to analyze its diagnostic value. Fibroosseous lesions of the jaws comprise a diverse group of conditions, which are characterized by replacement of normal bone by. Fibro osseous lesions fols are a generic designation of poorly defined group of lesions which are recognized to affect the jaws and the craniofacial bones which are known for their confusing area in diagnostic pathology. Dental college, regional institute of medical science, imphal, india. Fibroosseous lesion is a generic designation for a clinically diverse group of bone disorders in which the lesional tissue consists of large volumes of fibrous connective tissue, principally collagens type i and iii, as well as an osseous component in the form of woven or lamellar bone or cementum with varying degrees of mineralization. The benign fibroosseous lesions bfol represent a clinically diverse group of disorders of bone that share similar histopathologic features. Classification and, therefore, diagnosis of these lesions is difficult because there is significant overlap of clinical and histological features. Other cementoosseous dysplasias defined as lesions which share some of the features of periapical cemental dysplasia andor florid cementoosseous dysplasia, but do not have their characteristic clinicopathological patterns of.
Fibroosseous lesions of the oral and maxillofacial. Benign fibroosseous lesions bfol of the jaw, facial and skull bones are a variant group of intraosseous disease processes that share microscopic features 1 4. Jonathan swift 1667 1745 benign fibroosseous lesions. Recent world health organization classification 2005 for fibroosseous lesions was considered while subdividing these into.
Florid cement osseous dysplasia of maxilla and mandible. The purpose of this retrospective study was to evaluate the characteristics, treatment outcome of benign fibroosseous lesions of the jaws, in children, adolescents and adults. Summary this chapter demonstrates the variation in the radiological appearances of conditions of fibro. Fibro osseous lesions are characterized by the presence of bone marrow that has changed into fibrous tissue and that contains mineralized material of varying appearances. Molecular diagnosis of fibroosseous lesions of the oral. Focal osseous dysplasia fod is one of the benign fibro osseous lesions of the jaw bones and the most commonly occuring benign fibro osseous lesion. May, 2008 craniofacial bone lesions may be seen in both primary and secondary hyperparathyroidism hpt with benign fibroosseous lesions being more often reported among patients with renal osteodystrophy 145152. Clinical study of benign and malignant fibrousosseous. The diagnosis based on microscopy alone is often impossible due to overlapping of histopathologic features.
Whereas some are diagnosable histologically, most require a combined assessment of clinical, microscopic and radiologic features. Iyogun ca, dirisu n, omitola og and sule aa background. Benign fibroosseous lesions occur commonly in the jaw. Fibro osseous lesions of the jaws comprise a diverse group of conditions, which are characterized by replacement of normal bone by fibroblasts, collagen fibers, and mineralized tissue. Benign fibroosseous lesions bfol are relatively frequently observed yet most cases are sporadic in the jaws. These group of lesions predominantly affects the jaws and craniofacial bones.
Fibroosseous lesion fol is a broad term for a diverse group of jaw and craniofacial disorders that are often painless but grow progressively if uncontrolled. The classification of fol of the jaws has been an issue over time and. Jonathan swift 1667 1745 benign fibroosseous lesions a group of lesions in which normal bone is replaced initially by fibrous connective tissue over time, the lesion is infiltrated by osteoid. Introduction the term fibroosseous lesions fol has been used for many years as a general description for a group of. Nov 30, 2014 fibroosseous lesions the term fibroosseous lesion fol is a generic designation of a group of jaw disorders characterized by the replacement of bone by a benign connective tissue matrix. Growth of lesion usually ceases at the end of skeletal growth. Introduction the term fibroosseous lesions fol has been used for many years as a general description for a group of tumors and proliferative disorders, which. Cysts and cystlike lesions involving the jaws fibroosseous lesions of the jaws benign tumours involving the jaws malignant lesions involving the jaws vascular anomalies of the mid and lower face. Fibroosseous lesions 1 fibroosseous lesions dr shabeel pn 2 introduction. Apr 27, 2014 fibro osseous lesions of the jaws as a generic term used to describe a number of apparently different pathologic entities that commonly affect the maxilla, mandible and other facial bones1. Fibroosseous lesions fol are a poorly defined group of lesions affecting the jaws and craniofacial bones. Waldron, dds, msd in the first volume of the journal of oral surgery, dr g. The disease involves the normal architecture of bone is replaced by fibrous tissue containing varying amount of foci of mineralization. Maxillofacial fibroosseous lesions current diagnostic.
Some may be part of more generalized systemic disease. Fibroosseous lesions comprise a group of disorders characterized histologically by replacement of normal bone by cellular fibrous tissue within which varying amount of predominantly woven bone and acellular islands of mineralized tissue develops. The florid variant may involve the entire mandible 6. Cementoosseous dysplasia lesions may be expansile when associated with bone cysts or osteomyelitis fig 6. All are characterized by the replacement of bone by cellular fibrous tissue containing foci of mineralization that vary in amount and appearance. Get a printable copy pdf file of the complete article 1. Depending on the proportions of soft and mineralized tissue, they may be predominantly radiolucent, mixed radiodenseradiolucent, or mainly radiodense. Benign fibro osseous lesions bfol are relatively frequently observed yet most cases are sporadic in the jaws. Fibro osseous lesions of jaws were more in females 61. Fibroosseous lesions are grouped together because histologically they show similar cellular and mineralization patterns.
Benign fibro osseous lesion bfol is a distinct group of jaw entities composed of fibrocellular tissue and mineralized materials. Fibroosseous lesions fols are a poorly defined but pathologically diverse group of lesions affecting the craniofacial bones and jaw. Furthermore, distant metastasis should be checked through chest and abdominal ct scans every 3. Fibrous dysplasia may present with painless facial swelling and asymmetry. Fibro osseous lesions of jaw are a diverse group and since it may not be possible to adequately separate them. Pattern of fibro osseous lesions of jaws in port harcourt in southsouth nigeria authors. Atlas of oral and maxillofacial radiology electronic. Benign fibroosseous lesion bfol is a distinct group of jaw entities composed of fibrocellular tissue and mineralized materials. They represent a group of diverse diseases characterized by similar histopathologic features, 6. Fibrous dysplasia pathogenesis and histopathology youtube. Iadvances in omfs 19431993 j oral maxillofac surg 51. Fol is a generic designation given to a group of disorders ranging from inflammatory to neoplastic that microscopically exhibit, a connective tissue. Whereas some are diagnosable histologically, most require a combined assessment.
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